Chlorinated drinking water, diet and bladder cancer: A case-control study

Conference · · Archives of Environmental Health; (USA)

OSTI ID:5736900

Vena, J; Graham, S; Freudenheim, J; Marshall, J; Swanson, M; Sufrin, G ^[1]

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1. State Univ. of New York, Buffalo (USA)

The association between dietary factors and bladder cancer was investigated in 351 white males who had histologically confirmed transitional cell carcinomas of the bladder and 855 white male controls from Erie, Niagara, and Monroe Counties of Western New York State from November 1979 to November 1985. Usual diet and drinking water exposure was estimated by detailed interviews. After adjustment for age and other risk factors by multiple logistic regression, risk was found to increase with increasing pack-years of cigarettes when compared to that in the lowest quartile. Risk increased with daily intake of total liquids, with a 3.8 odds ratio in the highest quartile. A statistically significant inverse association was found between intake of carotene and risk of bladder cancer, especially at younger ages. The odds ratio for the highest quartiles of carotene consumption for those under age 65 y was 0.43. Logistic regression models for two age groups separately (< 65, 65+) suggested that daily intake of total liquids, sodium in the diet and carotene in the diet were the major predictors of risk under age 65. Cigarette smoking, carotene in the diet, and intake of total liquids were the major predictors of risk over age 65.

• OSTI ID: 5736900
• Report Number(s): CONF-890937--
• Conference Information: Journal Name: Archives of Environmental Health; (USA) Journal Volume: 45:5
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540310* -- Environment
Aquatic-- Basic Studies-- (1990-)
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BLADDER
BODY
CAROTENOIDS
CHLORINE COMPOUNDS
DIET
DISEASES
DRINKING WATER
HALOGEN COMPOUNDS
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
HYDROGEN COMPOUNDS
MAMMALS
MAN
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PIGMENTS
PRIMATES
TERPENES
URINARY TRACT
VERTEBRATES
WATER