Ceftriaxone-associated gallbladder sludge. Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate

Journal Article · Sat Jun 01 00:00:00 EDT 1991 · Gastroenterology; (USA)

OSTI ID:5735544

Park, H Z; Lee, S P; Schy, A L ^[1]

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1. Univ. of Washington School of Medicine, Seattle (USA)

Ceftriaxone, a third-generation cephalosporin, is partially excreted into bile. With its clinical use, the formation of gallbladder sludge detected by ultrasonography has been reported. Four surgical specimens were examined and no gallstones were found. Instead, fine precipitates of 20-250 microns were present. Microscopically, there was a small number of cholesterol monohydrate crystals and bilirubin granules among an abundant amount of granular-crystalline material that was not morphologically cholesterol monohydrate crystals. The chemical composition of the precipitates (n = 4) was determined. There was a small amount of cholesterol (1.7% +/- 0.8%) and bilirubin (13.9% +/- 0.74%). The major component of the precipitate was a residue. On further analysis using thin-layer chromatography, high-performance liquid chromatography, and electron microprobe analysis, the residue was identified as a calcium salt of ceftriaxone. The residue also had identical crystal morphology and chromatographic elution profile as authentic calcium-ceftriaxone standards. It is concluded that ceftriaxone, after excretion and being concentrated in the gallbladder bile, can form a precipitate. The major constituent has been identified as a ceftriaxone-calcium salt.

• OSTI ID: 5735544
• Journal Information: Gastroenterology; (USA), Journal Name: Gastroenterology; (USA) Vol. 100:6; ISSN GASTA; ISSN 0016-5085
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH METALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AZOLES
BILE
BILIARY TRACT
BILIRUBIN
BIOLOGICAL MATERIALS
BODY FLUIDS
CALCIUM
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
CHEMICAL COMPOSITION
CHOLESTEROL
CHROMATOGRAPHY
DIAGNOSIS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
ELECTRON MICROPROBE ANALYSIS
ELEMENTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MATERIALS
METABOLISM
METALS
MICROANALYSIS
NONDESTRUCTIVE ANALYSIS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PYRROLES
SEPARATION PROCESSES
STEROIDS
STEROLS
THIN-LAYER CHROMATOGRAPHY