Epidemiologic study of workers exposed to acrylonitrile: an update

Journal Article · Fri Nov 01 04:00:00 EST 1985 · JOM, J. Occup. Med.; (United States)

DOI:https://doi.org/10.1097/00043764-198511000-00018· OSTI ID:5735247

O'Berg, M T; Chen, J L; Burke, C A; Walrath, J; Pell, S

A previous report presented the cancer morbidity and mortality experience through 1976 of a cohort of 1345 male employees with potential for exposure to acrylonitrile at a fibers-producing plant. This study has now been updated through 1983 for cancer incidence and through 1981 for mortality. Overall, 43 cancer cases have occurred, with 37.1 expected based on company rates. A previously reported excess number of cases of lung cancer remains, but is not as marked (10 observed, 7.2 expected). Prostate cancer cases were significantly in excess, with six cases observed and 1.8 expected. Mortality analyses revealed 36 cancer deaths, with 31.6 expected. Of these, 14 were from lung cancer, with 11.6 expected based on company rates. Only one death from prostate cancer occurred, with 1.0 expected. To our knowledge, prostate cancer excesses have not been reported in any other acrylonitrile studies, and hence their significance is currently difficult to assess.

• OSTI ID: 5735247
• Journal Information: JOM, J. Occup. Med.; (United States), Journal Name: JOM, J. Occup. Med.; (United States) Vol. 11; ISSN JJOMD
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLONITRILE
BODY
CARCINOMAS
CHEMICAL INDUSTRY
DISEASES
EPIDEMIOLOGY
GLANDS
HAZARDS
HEALTH HAZARDS
INDUSTRY
LUNGS
MALE GENITALS
MORTALITY
NEOPLASMS
NITRILES
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERSONNEL
PROSTATE
RESPIRATORY SYSTEM