Transformation of chenodeoxycholic acid to ursodeoxycholic acid in patients with Crohn's disease

Journal Article · Sat Mar 01 04:00:00 EST 1986 · Gastroenterology; (United States)

OSTI ID:5734060

Miwa, H; Yamamoto, M; Nishida, T; Yao, T

In vivo 7 beta-epimerization of chenodeoxycholic acid to ursodeoxycholic acid and the role of 7-ketolithocholic acid as an intermediate in this biotransformation were studied in 11 patients with Crohn's disease and in 5 healthy volunteers. The incorporation of deuterium into biliary ursodeoxycholic acid and 7-ketolithocholic acid was determined by computed gas chromatography-mass fragmentography after ingestion of a dideuterated chenodeoxycholic acid, chenodeoxycholic-11,12-d2 acid. The incorporation of deuterium into ursodeoxycholic acid increased to a peak level at 48 h in the patients with Crohn's disease, but was delayed in healthy volunteers. In 8 patients and 2 healthy controls there were small amounts of 7-ketolithocholic acid in bile. The incorporation of deuterium into 7-ketolithocholic acid was confirmed in only 2 patients and the peak level was noted at 48 h. These observations suggest that 7-ketolithocholic acid is an intermediate of this biotransformation in patients with Crohn's disease.

• Research Organization: Fukuoka Univ., Japan
• OSTI ID: 5734060
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 3; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BILE
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BODY FLUIDS
CHEMICAL REACTIONS
CHEMISTRY
DEUTERATION
DEUTERIUM
DIGESTIVE SYSTEM DISEASES
DISEASES
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
MATERIALS
METABOLISM
METABOLITES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
PATIENTS
REACTION INTERMEDIATES
STABLE ISOTOPES
UPTAKE