A technetium-labeled monoclonal antibody for imaging metastatic melanoma

Journal Article · Mon Apr 01 00:00:00 EST 1991 · American Journal of Clinical Oncology; (USA)

DOI:https://doi.org/10.1097/00000421-199104000-00012· OSTI ID:5734016

Frytak, S; Creagan, E T; Brown, M L; Salk, D; Nelp, W ^[1]

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1. Mayo Clinic, Rochester, MN (USA)

Twenty patients with histologically proven metastatic melanoma were scanned with a 99mtechnetium ({sup 99}mTc)-labeled melanoma antibody to determine the detection rate of known malignant lesions and to evaluate the antibody's ability to discover occult metastases. Isotope localization in different organs was as follows: liver 100%, bone 100%, subcutaneous lesions 80%, lymph nodes 54%, and lung 33%. Four unsuspected bone lesions and 16 occult subcutaneous lesions were found. False positive lesions were noted in two instances--one benign thyroid adenoma, and one arthritic bone lesion. One patient developed an atypical serum sickness reaction with a rash and arthralgias that responded rapidly to treatment. The {sup 99}mTc antimelanoma antibody is a safe and effective method to detect metastatic melanoma. It has potential use for screening newly diagnosed melanomas that carry an increased risk of recurrence.

• OSTI ID: 5734016
• Journal Information: American Journal of Clinical Oncology; (USA), Vol. 14:2; ISSN 0277-3732
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MELANOMAS
DIAGNOSIS
RADIOIMMUNOSCINTIGRAPHY
SENSITIVITY ANALYSIS
ISOMERIC NUCLEI
METASTASES
MONOCLONAL ANTIBODIES
PATIENTS
TECHNETIUM 99
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
YEARS LIVING RADIOI
550601* - Medicine- Unsealed Radionuclides in Diagnostics