Effects of moderate-intensity light on vitamin A-deficient rat retinas
Journal Article
·
· Invest. Ophthalmol. Visual Sci.; (United States)
OSTI ID:5733670
The effects of moderate-intensity light (150 to 200 ft-cd) on retinal structure were compared between retinol-adequate and retinol-deficient rats after 1 to 6 days of light exposure during the 12 hr light phase of the cycle. Both damage to the outer segments and loss of photoreceptor cells were accelerated in retinol-adequate rats. Outer segments in retinas of retinol-adequate rats showed an abnormal staining pattern and disruption of disc structure in the distal portion about 2 days before those of retinol-deficient rats. After 4 days of exposure 24% of the photoreceptor cells had degenerated in the retinol-adequate retinas, but only 6% in the retinol-deficient retinas. By 6 days 65% and 41% of the photoreceptors had degenerated in the retinol-adequate and retinol-deficient retinas, respectively. Thus light exposure induced more rapid degeneration of photoreceptor cells in rats receiving adequate retinol than in those deficient in this vitamin.
- OSTI ID:
- 5733670
- Journal Information:
- Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 20:5; ISSN IOVSD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560100* -- Biomedical Sciences
Applied Studies-- Radiation Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CYTOLOGICAL TECHNIQUES
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
MAMMALS
NUTRITIONAL DEFICIENCY
ORGANS
PHOTOSENSITIVITY
RADIATION EFFECTS
RADIATIONS
RATS
RETINA
RODENTS
SENSE ORGANS
SENSITIVITY
VERTEBRATES
VISIBLE RADIATION
VITAMIN A
VITAMINS
Applied Studies-- Radiation Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CYTOLOGICAL TECHNIQUES
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
MAMMALS
NUTRITIONAL DEFICIENCY
ORGANS
PHOTOSENSITIVITY
RADIATION EFFECTS
RADIATIONS
RATS
RETINA
RODENTS
SENSE ORGANS
SENSITIVITY
VERTEBRATES
VISIBLE RADIATION
VITAMIN A
VITAMINS