Increased risk of lymphoma in sicca syndrome
Journal Article
·
· Ann. Intern. Med.; (United States)
The risk of cancer was ascertained in 136 women with sicca syndrome followed at the National Institutes of Health (NIH). Seven patients developed non-Hodgkin's lymphoma from 6 months to 13 years after their first admission to NIH. This was 43.8 times (P less than 0.01) the incidence expected from the rates of cancer prevailing among women of the same age range in the general population during this time. In addition, three cases of Waldenstroem's macroglobulinemia occurred in this study group. Eight patients developed cancers other than lymphoma, similar to the number expected based on the rates prevailing in the general population. Patients with a history of parotid enlargement, splenomegaly, and lymphadenopathy had an increased risk of lymphoma. These clinical conditions did not appear to be early manifestations of undiagnosed lymphoma but rather seemed to identify a subgroup of patients with sicca syndrome with marked lymphoid reactivity, who had a particularly high risk of subsequently developing lymphoma.
- Research Organization:
- National Institutes of Health, Bethesda, MD
- OSTI ID:
- 5731722
- Journal Information:
- Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 89:6; ISSN AIMEA
- Country of Publication:
- United States
- Language:
- English
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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
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FEMALES
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
PRIMATES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
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SIDE EFFECTS
THERAPY
VERTEBRATES
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560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
FEMALES
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
PRIMATES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
THERAPY
VERTEBRATES
WOMEN