Pharmacodynamic behavior of (/sup 14/C)acridine in the cricket Acheta domesticus (L. )

Journal Article · Sun Nov 01 04:00:00 EST 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530132· OSTI ID:5731265

Walton, B T; Maggart, Jr, E F

Cuticular and gastrointestinal penetration, in vivo metabolism, and excretion of (/sup 14/C)acridine were investigated in the nymphal cricket Acheta domesticus (L.) to find a pharmacodynamic basis for this insect's differential susceptibility to acridine at different life stages. Topically applied (/sup 14/C)acridine readily penetrated the cuticular exoskeleton of nymphs (half-time of penetration, 48 min). Radiolabeled compounds appeared in the hemolymph within 0.5 h after ingestion of (/sup 14/C)acridine and continued to move across the gut wall for 7.5 h. The biological half-time was 18 h and the rate constant for elimination was 0.039 h/sup -1/ after ingestion. Within 5 d after dosing, 97% of the dose was excreted. Several metabolites were present in the feces of nymphs fed (/sup 14/C)acridine, and less than 13% of the extractable radioactivity was parent compound. The cuticule and the gastrointestinal tract proved to be ineffective barriers to acridine entry in A. domesticus. However, the ability to readily metabolize and excrete acridine probably contributes to the higher acridine tolerance observed in the nymphs and adults than in the eggs, which are susceptible to toxic effects. Acridine is found in many coal and synthetic fuel by-products.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5731265
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 8:5-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACRIDINES
ANIMALS
ARTHROPODS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BY-PRODUCTS
CARBON 14 COMPOUNDS
CLEARANCE
COAL GASIFICATION
COAL LIQUEFACTION
DIGESTIVE SYSTEM
EXCRETION
FECES
GASIFICATION
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
IN VIVO
INGESTION
INSECTS
INTAKE
INTESTINAL ABSORPTION
INVERTEBRATES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIQUEFACTION
MATERIALS
METABOLISM
METABOLITES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
THERMOCHEMICAL PROCESSES
TRACER TECHNIQUES
UPTAKE
WASTES