Dose and time relationships in the endocrine response of the irradiated adult rat testis
Journal Article
·
· J. Androl.; (United States)
The dose- and time-dependent responses for the interstitial and tubular compartments in irradiated adult rat testes are described. Leydig cell dysfunction, as indicated by increased serum LH (to a maximum of 385% of control after 5 Gy) and decreased serum T (to a minimum of 30% of control after 10 Gy), was observed at 8 weeks postirradiation. Subsequent recovery of Leydig cell function was then observed, so that after 9 months serum T was normal but LH was still marginally elevated. The dysfunction, with a threshold of about 4 to 5 Gy, was associated with a loss of Leydig cells from the testis. Spermatogenic damage was observed; after doses of 3 Gy and above a marked dose-response was recorded as assessed by counts of tubule cross sections exhibiting spermatogenesis. Reduced serum levels of androgen binding protein indicated Sertoli cell dysfunction at 8 weeks after 3 Gy and above, with values of less than one half of those seen in the controls. Serum FSH also was elevated to between 150% and 200% of control, and after 9 months closely reflected androgen binding protein changes. Unlike the Leydig cell, no recovery with time was observed for this aspect of Sertoli cell function.
- Research Organization:
- Christie Hospital and Holt Radium Institute, Manchester, England
- OSTI ID:
- 5730331
- Journal Information:
- J. Androl.; (United States), Journal Name: J. Androl.; (United States) Vol. 1; ISSN JOAND
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
DOSE-RESPONSE RELATIONSHIPS
FSH
GERM CELLS
GONADOTROPINS
GONADS
HORMONES
HYDROXY COMPOUNDS
KETONES
LH
MALE GENITALS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RATS
RECOVERY
RODENTS
SPERMATOCYTES
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
TIME DEPENDENCE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
DOSE-RESPONSE RELATIONSHIPS
FSH
GERM CELLS
GONADOTROPINS
GONADS
HORMONES
HYDROXY COMPOUNDS
KETONES
LH
MALE GENITALS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RATS
RECOVERY
RODENTS
SPERMATOCYTES
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
TIME DEPENDENCE
VERTEBRATES