Interactions of ionizing radiation, nitrosamines, sulfonoxyalkanes and antioxidants as they affect carcinogenesis and survival in mice
Journal Article
·
· Am. Ind. Hyg. Assoc. J.; (United States)
Butylated hydroxytoluene (BHT) pretreatment of 8-wk-old BALB/c mice for 28 days protected against 30-day lethality by x-rays, diethylnitrosamine (DEN), dimethylnitrosamine (DMN) and ethyl methanesulfonate (EMS) but not against methyl methanesulfonate (MMS). In x-ray survivors, neither mean survival nor leukemia incidences were affected by BHT. However, BHT (lifetime), given alone or with DEN (300 mg/kg BW in H/sub 2/0) or 250 R x-rays, increased irradiated survivors at 18 months but not leukemia or tumor incidences. BHT + DEN treated females had increased survival and a decreased frequency of forestomach squamous carcinomas compared with DEN alone; no differences were seen in males or in pulmonary adenomas. In x-ray + DEN treated females, effect upon survival was additive, but the specific diseases causing this effect were not identified.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 5730301
- Journal Information:
- Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 39; ISSN AIHAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ALKANES
ANIMALS
ANTIOXIDANTS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
CARCINOMAS
CRESOLS
DISEASES
HEMIC DISEASES
HYDROCARBONS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
LEUKEMIA
MAMMALS
MICE
NEOPLASMS
NITROSO COMPOUNDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PHENOLS
RADIATION EFFECTS
RADIATIONS
RODENTS
SYNERGISM
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ALKANES
ANIMALS
ANTIOXIDANTS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
CARCINOMAS
CRESOLS
DISEASES
HEMIC DISEASES
HYDROCARBONS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
LEUKEMIA
MAMMALS
MICE
NEOPLASMS
NITROSO COMPOUNDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PHENOLS
RADIATION EFFECTS
RADIATIONS
RODENTS
SYNERGISM
VERTEBRATES