Ethylene oxide dose and dose-rate effects in the mouse dominant-lethal test

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860080102· OSTI ID:5729314

Generoso, W M; Cain, K T; Hughes, L A; Sega, G A; Braden, P W; Gosslee, D G; Shelby, M D

In the dose-response study, male mice were exposed by inhalation to ethylene oxide (EtO) for 4 consecutive days. Mice were exposed for 6 hr per day to 300 ppm, 400 ppm, or 500 ppm EtO for a daily total of 1800, 2400, or 3000 ppm X hr (total exposures of 7200, 9600 and 12,000 ppm X hr), respectively. In the dose-rate study, mice were given a total exposure of 1800 ppm X hr per day, also for 4 consecutive days, delivered either at 300 ppm in 6 hr, 600 ppm in 3 hr, or 1200 ppm in 1.5 hr. Quantitation of dominant-lethal responses was made on matings involving sperm exposed as late spermatids and early spermatozoa, the most sensitive stages to EtO. In the dose-response study, a dose-related increase in dominant-lethal mutations was observed, the dose-response curve proved to be nonlinear. In the dose-rate study, increasing the exposure concentrations resulted in increased dominant-lethal responses.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 5729314
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 1; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKENES
ANIMALS
DOSE-RESPONSE RELATIONSHIPS
ETHYLENE
HYDROCARBONS
INHALATION
INTAKE
MAMMALS
MICE
MUTAGENS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PREGNANCY
RODENTS
TOXICITY
VERTEBRATES