Radioprotection by leukotrienes: Is there a receptor mechanism. Scientific report
Leukotrienes are a class of biological mediators derived from arachidonic acid through the lipoxygenase pathway. Early studies showed that lipophilic factors capable of constricting smooth muscle and inducing anaphylaxis were produced in the guinea pig in response to cobra venom. Leukotrienes have pathological roles in inflammation and anaphylaxis, act as vasoactive agents, as chemotactic factors for neutrophils, and are more potent constrictors of smooth muscle than histamine. The lipoxygenase metabolites of arachidonic acid have not been as extensively characterized in terms of their cytoprotective and radioprotective properties as have the cyclooxygenase metabolites (prostaglandins, thromboxane, and prostacyclin). Research on the radioprotective properties of leukotrienes is limited by the expense and availability of pure compounds, and very little research has been done in this area thus far. Preliminary studies are presented here with the goal of discussing the current understanding of this problem and to introduce future research directions.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 5728451
- Report Number(s):
- AD-A-207918/4/XAB; AFRRI-SR-89-14
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANAPHYLAXIS
ANIMALS
ARACHIDONIC ACID
AZOLES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
DOCUMENT TYPES
DRUGS
EVALUATION
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
INFLAMMATION
MAMMALS
MONOCARBOXYLIC ACIDS
MUSCLES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
PROGRESS REPORT
PROSTAGLANDINS
RADIATION PROTECTION
RADIOPROTECTIVE SUBSTANCES
RODENTS
SENSE ORGANS
SYMPTOMS
VASOCONSTRICTORS
VENOMS
VERTEBRATES