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Title: Medulloblastoma in infants and children: computed tomographic follow-up after treatment

Abstract

Thirty-six proven cases of medulloblastoma were reviewed by serial CT follow-up examinations from 4 months to 10 years, 2 months after the initial diagnosis, with a mean follow-up time of 3 years, 9 months. The tumor recurred at the primary site in 20 cases (56%). Leptomeningeal metastasis was demonstrated on CT in 14 cases (39%); seven of these patients also presented with solid subarachnoid metastases. Thirteen patients (36%) showed evidence of severe brain atrophy, which was confined to the posterior fossa in seven of the 13. Calcification resulting from mineralizing microangiopathy developed in five cases (14%), including three patients who had had extensive dystrophic calcification in the corticomedullary junction and the deep-seated nuclei of the cerebrum and cerebellum. The patterns of tumor recurrence in the posterior fossa that is severely deformed by surgery and other treatment modalities and leptomeningeal spread of tumor are discussed.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, Houston
OSTI Identifier:
5728086
Report Number(s):
CONF-851152-
Journal ID: CODEN: RADLA; TRN: 85-015579
Resource Type:
Conference
Resource Relation:
Journal Name: Radiology; (United States); Journal Volume: 154:3; Conference: 71. scientific assembly and annual meeting, Chicago, IL, USA, 17 Nov 1985
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ATROPHY; RADIOINDUCTION; BRAIN; COMPUTERIZED TOMOGRAPHY; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; CALCINOSIS; CHILDREN; INFANTS; METASTASES; NEOPLASMS; AGE GROUPS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOLOGY; THERAPY; TOMOGRAPHY; 550602* - Medicine- External Radiation in Diagnostics- (1980-); 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Lee, Y.Y., Glass, J.P., van Eys, J., and Wallace, S.. Medulloblastoma in infants and children: computed tomographic follow-up after treatment. United States: N. p., 1985. Web.
Lee, Y.Y., Glass, J.P., van Eys, J., & Wallace, S.. Medulloblastoma in infants and children: computed tomographic follow-up after treatment. United States.
Lee, Y.Y., Glass, J.P., van Eys, J., and Wallace, S.. Fri . "Medulloblastoma in infants and children: computed tomographic follow-up after treatment". United States. doi:.
@article{osti_5728086,
title = {Medulloblastoma in infants and children: computed tomographic follow-up after treatment},
author = {Lee, Y.Y. and Glass, J.P. and van Eys, J. and Wallace, S.},
abstractNote = {Thirty-six proven cases of medulloblastoma were reviewed by serial CT follow-up examinations from 4 months to 10 years, 2 months after the initial diagnosis, with a mean follow-up time of 3 years, 9 months. The tumor recurred at the primary site in 20 cases (56%). Leptomeningeal metastasis was demonstrated on CT in 14 cases (39%); seven of these patients also presented with solid subarachnoid metastases. Thirteen patients (36%) showed evidence of severe brain atrophy, which was confined to the posterior fossa in seven of the 13. Calcification resulting from mineralizing microangiopathy developed in five cases (14%), including three patients who had had extensive dystrophic calcification in the corticomedullary junction and the deep-seated nuclei of the cerebrum and cerebellum. The patterns of tumor recurrence in the posterior fossa that is severely deformed by surgery and other treatment modalities and leptomeningeal spread of tumor are discussed.},
doi = {},
journal = {Radiology; (United States)},
number = ,
volume = 154:3,
place = {United States},
year = {Fri Mar 01 00:00:00 EST 1985},
month = {Fri Mar 01 00:00:00 EST 1985}
}

Conference:
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  • Radionuclide and computed tomographic (CT) scanning was performed for the long-term follow-up of 63 patients who had been treated for primary intracranial central nervous system tumors. This group included 23 children with supratentorial lesions and 40 with infratentorial lesions. The results of imaging were correlated with clinical assessment and the results of cytologic evaluation of the cerebrospinal fluid and, when available, surgical or autopsy findings. The sensitivity, specificity, and positive predictive value of both CT and radionuclide scanning were evaluated for each type of tumor. These two modalities play a complementary role in the long-term followup of children with primarymore » intra-axial neoplasms.« less
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