In vivo incorporation of labeled fatty acids in rat liver lipids after oral administration

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Lipids; (United States)

DOI:https://doi.org/10.1007/BF02537280· OSTI ID:5726261

Leyton, J; Drury, P J; Crawford, M A

Striking differences were found in the compartmentalization of fatty acids into liver lipid fractions. The saturated fatty acids--lauric, myristic, palmitic and stearic--were incorporated into phosphoglycerides at faster rates with increasing chain lengths, while triglyceride incorporation was almost uniform. The degree of incorporation of the unsaturated fatty acids into phosphoglycerides (structural) compared to triglyceride (storage and energy) was the converse of their oxidation rates. The incorporation of oleic, linoleic and alpha-linolenic acids was mainly into triglyceride, whereas dihomo-gamma-linolenic acid and arachidonic acid were preferentially incorporated into phosphoglycerides. The data suggest that distribution of each fatty acid is different depending on its destination for structural or energy function.

• Research Organization: Institute of Zoology, London, England
• OSTI ID: 5726261
• Journal Information: Lipids; (United States), Journal Name: Lipids; (United States) Vol. 22:8; ISSN LPDSA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOSYNTHESIS
BODY
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISTRIBUTION
ESTERS
GLANDS
IN VIVO
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIPIDS
LIVER
MAMMALS
METABOLISM
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
RADIOISOTOPES
RATS
RODENTS
SYNTHESIS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRIGLYCERIDES
VERTEBRATES