Imaging of experimental amyloidosis with /sup 131/I-labeled serum amyloid P component

Journal Article · Sun Nov 01 00:00:00 EST 1987 · Arthritis Rheum.; (United States)

DOI:https://doi.org/10.1002/art.1780301115· OSTI ID:5724006

Caspi, D; Zalzman, S; Baratz, M; Teitelbaum, Z; Yaron, M; Pras, M; Baltz, M L; Pepys, M B

/sup 131/I-labeled human serum amyloid P component, which was injected into mice with experimentally induced systemic AA amyloidosis and into controls, became specifically localized and was retained in amyloidotic organs. In comparison, it was rapidly and completely eliminated from unaffected tissues and from control animals. Distinctive images of this amyloid-specific deposition of labeled serum amyloid P component were derived from whole body scanning, in vivo, of amyloidotic mice. These findings suggest that such imaging may have applications for the diagnosis and quantitation of amyloid deposits in humans.

• Research Organization: Tel Aviv Univ., Israel
• OSTI ID: 5724006
• Journal Information: Arthritis Rheum.; (United States), Vol. 30:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
PROTEINS
TISSUE DISTRIBUTION
RHEUMATIC DISEASES
DIAGNOSIS
IODINE 131
MICE
RADIOISOTOPE SCANNING
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
RODENTS
SKELETAL DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics