Imaging of experimental amyloidosis with /sup 131/I-labeled serum amyloid P component

Journal Article · Sun Nov 01 04:00:00 EST 1987 · Arthritis Rheum.; (United States)

DOI:https://doi.org/10.1002/art.1780301115· OSTI ID:5724006

Caspi, D; Zalzman, S; Baratz, M; Teitelbaum, Z; Yaron, M; Pras, M; Baltz, M L; Pepys, M B

/sup 131/I-labeled human serum amyloid P component, which was injected into mice with experimentally induced systemic AA amyloidosis and into controls, became specifically localized and was retained in amyloidotic organs. In comparison, it was rapidly and completely eliminated from unaffected tissues and from control animals. Distinctive images of this amyloid-specific deposition of labeled serum amyloid P component were derived from whole body scanning, in vivo, of amyloidotic mice. These findings suggest that such imaging may have applications for the diagnosis and quantitation of amyloid deposits in humans.

• Research Organization: Tel Aviv Univ., Israel
• OSTI ID: 5724006
• Journal Information: Arthritis Rheum.; (United States), Journal Name: Arthritis Rheum.; (United States) Vol. 30:11; ISSN ARHEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISTRIBUTION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RHEUMATIC DISEASES
RODENTS
SKELETAL DISEASES
TISSUE DISTRIBUTION
VERTEBRATES