Activation of nuclear polypeptide synthesis in rat liver cells in the case of inhibition of template synthesis of proteins. Contribution of nuclear polypeptide synthesis to the change in the chromatin structure
Journal Article
·
· Biochemistry (Engl. Transl.); (United States)
OSTI ID:5721632
The correlation between the activity of nuclear polypeptide synthesis (NPS) and template synthesis of proteins in rat liver cells was investigated. It was established that the NPS is activated under conditions of inhibition of protein synthesis in the cytoplasm. It was shown on model experiments that the systems of NPS and ADP-ribosylation of nuclear proteins compete in determining the general structure of chromatin: ADP-ribosylation promotes condensation, while NPS promotes decondensation of the chromatin.
- Research Organization:
- Institute of Chemical Physics, Chernogolovka, USSR
- OSTI ID:
- 5721632
- Journal Information:
- Biochemistry (Engl. Transl.); (United States), Vol. 50:12; Other Information: Translated from Biokhimiya; 50: No.12, 1990-1995(Dec 1985)
- Country of Publication:
- United States
- Language:
- English
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+1 more
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CHROMATIN
MOLECULAR STRUCTURE
LIVER CELLS
BIOCHEMISTRY
TRACER TECHNIQUES
POLYPEPTIDES
BIOSYNTHESIS
METABOLIC ACTIVATION
CARBON 14 COMPOUNDS
CELL CYCLE
CYCLOHEXIMIDE
CYTOPLASM
DNA
GLUTAMIC ACID
LIVER
PROTEINS
RADIOACTIVITY
RATS
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
THYMIDINE
UPTAKE
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AZINES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHEMISTRY
DIGESTIVE SYSTEM
DRUGS
FUNGICIDES
GLANDS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
PESTICIDES
PYRIMIDINES
RIBOSIDES
RODENTS
SOMATIC CELLS
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550301 - Cytology- Tracer Techniques
CHROMATIN
MOLECULAR STRUCTURE
LIVER CELLS
BIOCHEMISTRY
TRACER TECHNIQUES
POLYPEPTIDES
BIOSYNTHESIS
METABOLIC ACTIVATION
CARBON 14 COMPOUNDS
CELL CYCLE
CYCLOHEXIMIDE
CYTOPLASM
DNA
GLUTAMIC ACID
LIVER
PROTEINS
RADIOACTIVITY
RATS
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
THYMIDINE
UPTAKE
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AZINES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHEMISTRY
DIGESTIVE SYSTEM
DRUGS
FUNGICIDES
GLANDS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
PESTICIDES
PYRIMIDINES
RIBOSIDES
RODENTS
SOMATIC CELLS
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550301 - Cytology- Tracer Techniques