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Persistence of cadmium-induced metabolic changes in liver and kidney

Journal Article · · Science (Washington, D.C.); (United States)
; ; ;

Daily intraperitoneal injection of cadmium chloride (1 milligram per kilogram) for 45 days enhanced gluconeogenesis as evidenced by significant increases in the activities of liver and kidney cortex pyruvate carboxylase, phosphopyruvate carboxylase, hexosediphosphatase, and glucose-6-phosphatase, the quartet of key, rate-limiting enzymes involved in the biotransformation of non-carbohydrate precursors into glucose. Whereas cadmium treatment decreased the level of hepatic glycogen, the concentration of blood glucose and urea was significantly elevated by this heavy metal. Discontinuation of the heavy metal treatment for 28 days, in rats previously injected with cadmium for 45 days, failed to restore the observed biochemical alterations in hepatic and renal carbohydrate metabolism to control values. Evidence indicates that cadmium augments the glucose-synthesizing capacity of liver and kidney cortex and that various metabolic changes persist even after a 4-week period of withdrawal from exposure to the heavy metal. 14 references, 2 tables.

Research Organization:
Univ. of Ottawa, Ontario
OSTI ID:
5720291
Journal Information:
Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 183:4129; ISSN SCIEA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BLOOD CHEMISTRY
BODY
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBOHYDRATES
CARBOXYLASE
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ESTERASES
GLANDS
GLUCOSE
HALIDES
HALOGEN COMPOUNDS
HEXOSES
HYDROLASES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
LIGASES
LIVER
MAMMALS
METABOLISM
METALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PHOSPHATASES
RATS
RODENTS
SACCHARIDES
STIMULATION
SYNTHESIS
VERTEBRATES