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Temporary ovarian failure in thyroid cancer patients after thyroid remnant ablation with radioactive iodine

Journal Article · · J. Clin. Endocrinol. Metab.; (United States)
We studied ovarian function retrospectively in 66 women who had regular menstrual cycles before undergoing complete thyroidectomy for differentiated thyroid cancer and subsequent thyroid remnant ablation with /sup 131/I. Eighteen women developed temporary amenorrhea accompanied by increased serum gonadotropin concentrations during the first year after /sup 131/I therapy. No correlation was found between the radioactive iodine dose absorbed, thyroid uptake before treatment, oral contraceptive use, or thyroid autoimmunity. Only age was a determining factor, with the older women being the most affected. We conclude that radioiodine ablation therapy is followed by transient ovarian failure, especially in older women.
Research Organization:
Hopital Bichat, Paris (France)
OSTI ID:
5717279
Journal Information:
J. Clin. Endocrinol. Metab.; (United States), Journal Name: J. Clin. Endocrinol. Metab.; (United States) Vol. 69:1; ISSN JCEMA
Country of Publication:
United States
Language:
English