Enhanced sensitivity of muscarinic cholinergic receptor associated with dopaminergic receptor subsensitivity after chronic antidepressant treatment

Journal Article · Mon Mar 09 04:00:00 EST 1981 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(81)90691-3· OSTI ID:5714169

Koide, T; Matsushita, H

The chronic effects of antidepressant treatment on striatal dopaminergic (DA) and muscarinic cholinergic (mACh) receptors of the rat brain have been examined comparatively in this study using /sup 3/H-spiroperidol (/sup 3/H-SPD) and /sup 3/H-quinuclidinyl benzilate (/sup 3/H-QNB) as the respective radioactive ligands. Imipramine and desipramine were used as prototype antidepressants. Although a single administration of imipramine or desipramine did not affect each receptor sensitivity, chronic treatment with each drug caused a supersensitivity of mACh receptor subsequent to DA receptor subsensitivity. Furthermore, it has been suggested that anti-mACh properties of imipramine or desipramine may not necessarily be related to the manifestation of mACh receptor supersensitivity and that sustained DA receptor subsensitivity may play some role in the alterations of mACh receptor sensitivity.

• Research Organization: Research Lab. of Chugai Pharmaceutical Co., Ltd., Tokyo, Japan
• OSTI ID: 5714169
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 28:10; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
ANTIDEPRESSANTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHRONIC INTAKE
DRUGS
HETEROCYCLIC COMPOUNDS
IMIPRAMINE
INTAKE
LABELLED COMPOUNDS
LIGANDS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
RATS
RECEPTORS
RODENTS
SENSITIVITY
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES