Effects of low-level microwave irradiation on hippocampal and frontal cortical choline uptake are classically conditionable

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · Pharmacol., Biochem. Behav.; (United States)

DOI:https://doi.org/10.1016/0091-3057(87)90186-9· OSTI ID:5711688

Lai, H; Horita, A; Chou, C K; Guy, A W

In previous research, we found that sodium-dependent high-affinity choline uptake in the hippocampus and frontal cortex of the rat was lowered after acute (45 min) exposure to low-level 2450-MHz pulsed microwaves (power density 1 mW/cm2; average whole body specific absorption rate, 0.6 W/kg; 2 mu sec pulses, 500 pps). In the present experiment, we investigated developments of tolerance and classical conditioning to these effects of microwaves. Rats were exposed to microwaves in cylindrical waveguides in 10 daily sessions (45 min per session). In an 11th session, we subjected the rats to either microwave (study of tolerance) or sham exposure (study of conditioned effect) for 45 min, and immediately measured choline uptake in the hippocampus and frontal cortex. We found that tolerance, a decrease in response to microwaves, developed to the effect of microwaves on choline uptake in the hippocampus, but not in the frontal cortex. Conditioned effects were also observed: an increase in choline uptake in the hippocampus and a decrease in uptake in the frontal cortex. These data suggest that the effects of microwaves on choline uptake in the hippocampus and frontal cortex are classically conditionable, probably to cues in the exposure environment.

• Research Organization: Univ. of Washington School of Medicine, Seattle
• OSTI ID: 5711688
• Journal Information: Pharmacol., Biochem. Behav.; (United States), Journal Name: Pharmacol., Biochem. Behav.; (United States) Vol. 27:4; ISSN PBBHA
• Country of Publication: United States
• Language: English

Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALKALI METALS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHOLINE
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
HIPPOCAMPUS
HYDROXY COMPOUNDS
LIPOTROPIC FACTORS
MAMMALS
METALS
MICROWAVE RADIATION
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
QUATERNARY COMPOUNDS
RADIATIONS
RATS
RODENTS
SODIUM
TOLERANCE
UPTAKE
VERTEBRATES