Brain blood flow measured with intravenous H/sub 2/ /sup 15/O. II. Implementation and validation

Journal Article · Thu Sep 01 04:00:00 EDT 1983 · J. Nucl. Med.; (United States)

OSTI ID:5707739

Raichle, M E; Martin, W R.W.; Herscovitch, P; Mintun, M A; Markham, J

The well-known tissue autoradiographic technique for the measurement of regional cerebral blood flow (CBF), originally proposed by Kety and his colleagues has been adapted for the measurement of CBF in human subjects using positron emission tomography (PET) and intravenously administered oxygen-15-labeled water. This report describes the steps necessary for the implementation of this PET/autoradiographic technique. In order to establish the accuracy of the method, we measured CBF with intravenously administered oxygen-15-labeled water and PET in anesthetized adult baboons and compared the results with blood flow measured by a standard tracer technique that uses residue detection of a bolus of oxygen-15-labeled water injected into the internal carotid artery. The correlation between CBF measured with PET and the true CBF for the same cerebral hemisphere was excellent.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 5707739
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
APES
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
TESTING
TOMOGRAPHY
VALIDATION
VERTEBRATES
WATER