Assessment of clinical significance of anti-Ge in an untransfused man

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Transfusion (Philadelphia); (USA)

DOI:https://doi.org/10.1046/j.1537-2995.1991.31391165177.x· OSTI ID:5706390

Pearson, H A; Richards, V L; Wylie, B R; Bruce, D; Watt, J M; Wilkie, D; Kronenberg, H ^[1]

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1. New South Wales Red Cross Blood Transfusion Service, Sydney (Australia)

A 19-year-old, untransfused Melanesian man from Papua New Guinea was admitted to the hospital for repair of an atrial septal defect. His serum contained an alloantibody that reacted strongly on the indirect antiglobulin test and was identified as anti-Ge. Gerbich-negative blood was transfused following urgent surgery. A 51Cr red cell survival study performed 2 weeks after surgery yielded zero survival of Gerbich-positive cells after 24 hours. A monocyte-driven, antibody-dependent, cell-mediated cytotoxicity assay performed on both pretransfusion and posttransfusion serum samples and on concentrated serum showed less than 1 percent specific lysis of Gerbich-positive cells. This did not correlate with the indication of clinical significance predicted by the 51Cr study. Red cell adherence and phagocytosis, not evident in a monocyte monolayer assay using native serum, were demonstrable in 16 percent of monocytes by the use of concentrated serum.

• OSTI ID: 5706390
• Journal Information: Transfusion (Philadelphia); (USA), Journal Name: Transfusion (Philadelphia); (USA) Vol. 31:3; ISSN TRANA; ISSN 0041-1132
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADHESION
ASIA
AUSTRALASIA
BETA DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD GROUPS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
CONGENITAL MALFORMATIONS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
IMMUNE REACTIONS
INTERMEDIATE MASS NUCLEI
ISLANDS
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LYSIS
MALFORMATIONS
MATERIALS
MONOCYTES
NEW GUINEA
NUCLEI
PAPUA NEW GUINEA
PATHOLOGICAL CHANGES
PHAGOCYTOSIS
RADIOISOTOPES
SURVIVAL TIME
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS