Rabbit lungs after long-term exposure to low nickel dust concentration. I. Effects on phospholipid concentration and surfactant activity

Journal Article · Tue Feb 01 04:00:00 EST 1983 · Environ. Res.; (United States)

OSTI ID:5706214

Curstedt, T ^[1]; Hagman, M; Robertson, B; Camner, P

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1. Karolinska Hospital, Stockholm, Sweden

Rabbits were exposed for 4 to 8 months (5 days/week, 6 hr/day) to 0.13 + 0.05 mg/m/sup 3/ (mean + SD) of metallic nickel dust. After exposure the left lung was homgenized and its content of phospholipids as well as the concentration and composition of the phosphatidylcholines were estimated. The right lung was lavaged and the surface tension of the lavage fluid was studied with a pulsating bubble technique. Both exposed groups showed a similar increase in total phospholipids, about 20% in the upper lobe and 30% in the lower lobe. The increase was mainly, possibly totally, due to an elevated level of phosphatidylcholines, especially disaturated species. Surface tension was significantly lower in exposed rabbits after 4 months of exposure but it was similar to that of the controls after 8 months.

• OSTI ID: 5706214
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 30:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
DUSTS
ELEMENTS
ESTERS
INJURIES
LIPIDS
LUNGS
MAMMALS
METALS
NICKEL
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
RABBITS
RESPIRATORY SYSTEM
SENSITIVITY
SURFACE PROPERTIES
SURFACE TENSION
SURFACTANTS
TRANSITION ELEMENTS
VERTEBRATES