Effects of ethylene glycol monomethyl ether on various parameters of testicular function in the F344 rat
These studies were designed to define the target cell for ethylene glycol monomethyl ether (EGME) action in the rodent testis, and to compare fluid production and protein secretory patterns in the testes of treated and control animals. Adult F344 rats were treated with 150 mg/kg/day, 5 day/week, and sacrificed 1, 2, 4, 7, or 10 days after the first dose. In the testes of treated animals, the most sensitive cells were the premeiotic and meiotic spermatocytes. As length of treatment continued, the younger transitional spermatocytes, and more pachytene spermatocytes, were affected. Early and late stage spermatids did not appear affected, nor was the visual appearance of spermatogonia changed by exposure to EGME. Fluid production, androgen-binding protein secretion and electrophoreograms of proteins found in the ligated rete testis were also unchanged by EGME, showing that these indices of Sertoli cell function were not affected by EGME. The histologic and biochemical data suggest that both early and late spermatocytes are targets for EGME in the testis, and that the Sertoli cells are relatively unaffected. 11 references, 4 figures, 1 table.
- Research Organization:
- National Inst. of Environmental Health Sciences, Research Triangle Park, NC
- OSTI ID:
- 5705840
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 57; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
ETHERS
GAMETES
GERM CELLS
GLYCOLS
GONADS
HYDROXY COMPOUNDS
MALE GENITALS
MAMMALS
MATERIALS
METHYL ETHER
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
SENSITIVITY
SPERMATOCYTES
SPERMATOGONIA
TESTES
TOXICITY
VERTEBRATES