Transfer of plasma lipoprotein components and of plasma proteins into aortas of cholesterol-fed rabbits. Molecular size as a determinant of plasma lipoprotein influx

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Arteriosclerosis; (United States)

DOI:https://doi.org/10.1161/01.ATV.1.1.38· OSTI ID:5705328

Stender, S; Zilversmit, D B

The arterial influx of esterified and free cholesterol from low density lipoproteins and very low density lipoproteins in 20 hypercholesterolemic rabbits was measured simultaneously by the use of lipoproteins labeled in vivo with (/sup 3/H)- and (/sup 14/C)-cholesterol. The simultaneous arterial influx of either (/sup 3/H)-leucine-labeled very low density lipoproteins, low density lipoproteins, high density lipoproteins, or plasma proteins was also measured in each rabbit. The arterial influx was calculated as intimal clearance, i.e., the influx of a given fraction divided by its plasma concentration. The intimal clearance of low density lipoprotein esterified cholesterol was equal to that for the apolipoproteins of that fraction, which is compatible with an arterial influx of intact low density lipoprotein molecules. The intimal clearance of very low density apolipoprotein or cholesteryl ester was less than that for low density lipoprotein, whereas high density lipoprotein and albumin clearances exceeded low density lipoprotein clearance by 1.5- to 3-fold. The intimal clearances of plasma proteins, high density, low density, and very low density lipoproteins decreased linearly with the logarithm of the macromolecular diameter. This indicates that the arterial influx of three plasma lipoprotein fractions and of plasma proteins proceeds by similar mechanisms. Apparently the relative intimal clearances of lipoproteins are more dependent on their size relative to pores or vesicular diameters at the plasma-artery interface than on specific interactions between lipoproteins and the arterial intimal surface.

• Research Organization: Division of Nutritional Sciences Cornell University, Ithaca, New York
• OSTI ID: 5705328
• Journal Information: Arteriosclerosis; (United States), Journal Name: Arteriosclerosis; (United States) Vol. 1:1
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AORTA
ARTERIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BLOOD VESSELS
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CARDIOVASCULAR SYSTEM
CHOLESTEROL
CLEARANCE
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
LIPIDS
LIPOPROTEINS
MAMMALS
MASS TRANSFER
MATERIALS
MOLECULAR WEIGHT
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RABBITS
STEROIDS
STEROLS
TRITIUM COMPOUNDS
VERTEBRATES