Lymphocyte cytotoxicity in the x-irradiation induced rat small bowel adenocarcinoma. II. Presence of cytotoxic lymphocytes in irradiated animals
Journal Article
·
· Immunol. Commun.; (United States)
Cytotoxic peripheral blood lymphoid cells were demonstrated in both Holtzman and Lewis Brown-Norway rats which had received 2000 R of local x-irradiation to the temporarily hypoxic, exteriorized, ileum and jejunum regardless of whether a small bowel adenocarcinoma subsequently developed. The cytotoxic response, which was detectable at two days, was quite evident by day 5 post-irradiation. No evidence of cross-reacting tumor antigens was obtained when similarly processed effector cells from Holtzman rats bearing a spontaneous mammary carcinoma were incubated with cell cultures derived from the small bowel adenocarcinoma. These findings indicate x-irradiation of the small bowel initiates lymphocyte sensitization that is manifested as in vitro cytotoxicity against cell cultures of the adenocarcinoma.
- Research Organization:
- Univ. of Iowa, Iowa City
- OSTI ID:
- 5705224
- Journal Information:
- Immunol. Commun.; (United States), Journal Name: Immunol. Commun.; (United States) Vol. 7:3; ISSN IMLCA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Lymphocyte cytotoxicity in x-irradiation induced rat small bowel adenocarcinoma. IV. Activation of cellular immunity by x irradiation
Circulating blocking factors of lymphoid-cell cytotoxicity in x-ray-induced rat small-bowel adenocarcinoma
Antibody-dependent cell-mediated cytotoxicity in x-irradiation-induced adenocarcinoma of the rat small bowel
Journal Article
·
Sun Dec 31 23:00:00 EST 1978
· Radiology; (United States)
·
OSTI ID:6469403
Circulating blocking factors of lymphoid-cell cytotoxicity in x-ray-induced rat small-bowel adenocarcinoma
Journal Article
·
Mon Oct 01 00:00:00 EDT 1979
· Radiat. Res.; (United States)
·
OSTI ID:5794618
Antibody-dependent cell-mediated cytotoxicity in x-irradiation-induced adenocarcinoma of the rat small bowel
Journal Article
·
Tue Sep 01 00:00:00 EDT 1981
· Radiat. Res.; (United States)
·
OSTI ID:6141717
Related Subjects
560111 -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARCINOMAS
CELL CULTURES
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
IMMUNE REACTIONS
INTESTINES
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LOCAL IRRADIATION
LYMPHOCYTES
MAMMALS
MATERIALS
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SMALL INTESTINE
SOMATIC CELLS
TIME DEPENDENCE
VERTEBRATES
X RADIATION
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARCINOMAS
CELL CULTURES
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
IMMUNE REACTIONS
INTESTINES
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LOCAL IRRADIATION
LYMPHOCYTES
MAMMALS
MATERIALS
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SMALL INTESTINE
SOMATIC CELLS
TIME DEPENDENCE
VERTEBRATES
X RADIATION