Binding sites for endothelin-1 in rat tissues: An autoradiographic study

Journal Article · Sun Jan 01 04:00:00 EST 1989 · J. Cardiovasc. Pharmacol.; (United States)

DOI:https://doi.org/10.1097/00005344-198900135-00040· OSTI ID:5702926

Koseki, C; Imai, M; Hirata, Y; Yanagisawa, M; Masaki, T

By tissue autoradiography in the rat, we demonstrated that receptors for endothelin-1 (ET-1) were distributed not only in the cardiovascular system but also in the noncardiovascular organs including the brain, lung, intestine, etc. In the brain, the receptors were mainly found in the basal ganglia and brainstem, in which nuclei are known to be cardiovascular regulatory sites. In addition to its direct vasoconstricting action, ET-1 may exert neural cardiovascular control as a neuropeptide.

• Research Organization: National Cardiovascular Center Research Institute, Osaka (Japan)
• OSTI ID: 5702926
• Journal Information: J. Cardiovasc. Pharmacol.; (United States), Journal Name: J. Cardiovasc. Pharmacol.; (United States) Vol. 13 Suppl 5; ISSN JCPCD
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
DRUGS
HEART
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEMBRANE PROTEINS
MICROSOMES
MUSCLES
MYOCARDIUM
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PEPTIDES
PROTEINS
RATS
RECEPTORS
RIBOSOMES
RODENTS
TISSUE DISTRIBUTION
VASOCONSTRICTORS
VERTEBRATES