Allelic loss of chromosomes 16q and 10q in human prostate cancer

Journal Article · Thu Nov 01 04:00:00 EST 1990 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.87.22.8751· OSTI ID:5701741

Carter, B S; Ewing, C M; Ward, W S; Treiger, B F; Isaacs, W B; Epstein, J I ^[1]; Aalders, T W; Schalken, J A ^[2]

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1. Johns Hopkins Medical Inst., Baltimore, MD (United States)
2. Univ. of Nijmegen (Netherlands)

Recent advances in understanding the molecular genetics of common adult tumors have indicated that multiple genetic alterations including the activation of oncogenes and the inactivation of tumor suppressor genes are important in the pathogenesis of these tumors. Loss of heterozygosity is a hallmark of tumor suppressor gene inactivation and has been used to identify chromosomal regions that contain these genes. The authors have examines allelic loss in the most common tumor in men, prostate cancer. Twenty-eight prostate cancer specimens have been examined for loss of heterozygosity at 11 different chromosomal arms including 3p, 7q, 9q, 10p, 10q, 11p, 13q, 16p, 17p, and 18q. Fifty-four percent (13/24) of clinically localized tumors and 4 of 4 metastatic tumors showed loss of heterozygosity on at least one chromosome. Chromosomes 16q and 10q exhibited the highest frequency of loss of heterozygosity with 30% of tumors showing loss at these chromosomes. These data demonstrate that allelic loss is a common event in prostate cancer and suggest that chromosomes 16q and 10q may contain the sites of tumor suppressor genes important in the pathogenesis of human prostate cancer.

• OSTI ID: 5701741
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 87:22; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BODY
CARCINOGENESIS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DISEASES
DNA HYBRIDIZATION
GENE REGULATION
GLANDS
HETEROCHROMOSOMES
HUMAN CHROMOSOME 16
HUMAN CHROMOSOMES
HYBRIDIZATION
MALE GENITALS
MUTATIONS
NEOPLASMS
ORGANS
PATHOGENESIS
PATIENTS
PROSTATE