( sup 3 H)Dopamine uptake by platelet storage granules in schizophrenia

Journal Article · Wed Jan 01 00:00:00 EST 1992 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(92)90198-X· OSTI ID:5699055

Rabey, J M; Graff, E; Oberman, Z ^[1]; Lerner, A; Sigal, M ^[2]

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1. Tel-Aviv Sourasky Medical Center (Israel)
2. Tel-Aviv Univ. (Israel)

({sup 3}H)Dopamine (DA) uptake by platelet storage granules was determined in 26 schizophrenic male patients, paranoid type (14 acute stage; 12 in remission) and 20 age-matched, normal controls. maximum velocity (Vmax) of DA uptake was significantly higher in acute patients, than patients in remission or controls (p>0.05). The apparent Michaelis constant (kM) of DA uptake in acute patients was also significantly different from chronic patients a substantial diminution of DA uptake, while haloperidol produced a substantial diminution of DA uptake, while haloperidol (10{sup {minus}4}, 10{sup {minus}5} M) did not affect the assay. Considering that a DA disequilibrium in schizophrenia may be expressed not only in the brain, but also in the periphery and that an increased amount of DA accumulated in the vesicles, implies that an increased quantity of catecholamine is available for release, our findings suggest additional evidence for the role of DA overactivity in the pathophysiology of this disorder.

• OSTI ID: 5699055
• Journal Information: Life Sciences; (United States), Vol. 50:1; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
UPTAKE
NERVOUS SYSTEM DISEASES
PATHOGENESIS
BLOOD PLATELETS
PATIENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DISEASES
DRUGS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
MATERIALS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
SYMPATHOMIMETICS
550201* - Biochemistry- Tracer Techniques