Synthesis of (/sup 75/Se)trimethylselenonium iodide from (/sup 75/Se)selenocystine
Journal Article
·
· Anal. Biochem.; (United States)
The synthesis of (/sup 75/Se)trimethylselenonium iodide from (/sup 75/)selenocystine is described. The starting compound is reduced to (/sup 75/Se)selenocysteine with borohydride and reacted with methyl iodide to form (/sup 75/Se)Se-methyl-selenocysteine, then treated with methyl iodide in formic acid solution to form Se-dimethyl-selenocysteine selenonium iodide. Over a period of days, the selenonium intermediate undergoes spontaneous elimination to form alanine and dimethyl selenide, which reacts with methyl iodide to give the trimethylselenonium product in over 90% yield. 15 references.
- Research Organization:
- Univ. of Wisconsin, Madison
- OSTI ID:
- 5696622
- Journal Information:
- Anal. Biochem.; (United States), Journal Name: Anal. Biochem.; (United States) Vol. 137:1; ISSN ANBCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODIDES
IODINE COMPOUNDS
ISOTOPES
LABELLING
METABOLITES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
REDUCTION
SELENIUM 75
SELENIUM COMPOUNDS
SELENIUM IODIDES
SELENIUM ISOTOPES
SYNTHESIS
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODIDES
IODINE COMPOUNDS
ISOTOPES
LABELLING
METABOLITES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
REDUCTION
SELENIUM 75
SELENIUM COMPOUNDS
SELENIUM IODIDES
SELENIUM ISOTOPES
SYNTHESIS