Synthesis of (/sup 75/Se)trimethylselenonium iodide from (/sup 75/Se)selenocystine

Journal Article · Wed Feb 15 00:00:00 EST 1984 · Anal. Biochem.; (United States)

DOI:https://doi.org/10.1016/0003-2697(84)90371-3· OSTI ID:5696622

Foster, S J; Ganther, H E

The synthesis of (/sup 75/Se)trimethylselenonium iodide from (/sup 75/)selenocystine is described. The starting compound is reduced to (/sup 75/Se)selenocysteine with borohydride and reacted with methyl iodide to form (/sup 75/Se)Se-methyl-selenocysteine, then treated with methyl iodide in formic acid solution to form Se-dimethyl-selenocysteine selenonium iodide. Over a period of days, the selenonium intermediate undergoes spontaneous elimination to form alanine and dimethyl selenide, which reacts with methyl iodide to give the trimethylselenonium product in over 90% yield. 15 references.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 5696622
• Journal Information: Anal. Biochem.; (United States), Vol. 137:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
REDUCTION
SELENIUM COMPOUNDS
SYNTHESIS
LABELLING
METABOLITES
SELENIUM 75
SELENIUM IODIDES
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODIDES
IODINE COMPOUNDS
ISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
SELENIUM ISOTOPES
550201* - Biochemistry- Tracer Techniques