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SAS probit analysis for cadmium mortality

Journal Article · · Environ. Res.; (United States)
; ;
In the quantitation of heavy metal effectiveness it is useful to compute the median lethal dose (LD/sub 50/) to the exposed population. The computerized Statistical Analysis System (SAS) of probit analysis is particularly useful in analyzing dose-response data because it is more accurate than the graphical methods currently in use and, in addition, provides fiducial limits with its estimates. Acute and chronic cadmium mortalities of yound adult male and female Sprague-Dawley rats were determined by the SAS probit analysis. When male and female rats were administered comparable doses of cadmium chloride, based on individual body weights, males were more susceptible. A plausible explanation for this greater sensitivity of males to the heavy metal is testicular necrosis. The acute LD/sub 50//sub (30 days)/ value for males was 5.99 mg Cd/kg body wt, with 95% fiducial limits of 4.71-7.54 mg Cd/kg body wt, as compared to 7.13 (5.18-8.85) mg Cd/kg body wt for females. When multiple (chronic doses of cadmium were injected, LD/sub 50//sub (30 days)/ values were 4.25 (3.42-5.05( mg Cd/kg body wt and 5.14 (4.42-5.92) mg Cd/kg body wt for males and females, respectively. Chronic LD values indicate an increase in effectiveness of dose as time of injections was protracted.
Research Organization:
Texas Woman's Univ., Denton
OSTI ID:
5695660
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 29:1; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELEMENTS
GONADS
HALIDES
HALOGEN COMPOUNDS
LETHAL DOSES
MALE GENITALS
MAMMALS
MATHEMATICS
METALS
MORTALITY
NECROSIS
ORGANS
PATHOLOGICAL CHANGES
RATS
RODENTS
STATISTICS
TESTES
VERTEBRATES