Effects of N-acetylimidazole on oxytocin binding in bovine mammary tissue

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Journal of Receptor Research; (USA)

DOI:https://doi.org/10.3109/10799899009064671· OSTI ID:5685065

Zhao, X; Gorewit, R C; Currie, W B ^[1]

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1. Cornell Univ., Ithaca NY (USA)

The effects of N-acetylimidazole on specific binding of oxytocin to microsomal fractions of bovine mammary gland were studied. N-acetylimidazole suppressed oxytocin binding, with time and concentration dependence. Decreased oxytocin binding activity appeared to be due to decreased affinity of the hormone for its receptor. Acetylation of oxytocin, rather than of oxytocin receptors, seemed to be responsible for the decreased binding.

• OSTI ID: 5685065
• Journal Information: Journal of Receptor Research; (USA), Vol. 10:5-6; ISSN 0197-5110
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
IMIDAZOLES
BIOCHEMICAL REACTION KINETICS
OXYTOCIN
ACETYLATION
AFFINITY
CATTLE
DOSE-RESPONSE RELATIONSHIPS
IN VITRO
MAMMARY GLANDS
MICROSOMES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ACYLATION
ANIMALS
AZOLES
BODY
CELL CONSTITUENTS
CHEMICAL REACTIONS
DOMESTIC ANIMALS
GLANDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
REACTION KINETICS
RIBOSOMES
RUMINANTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques