Effects of N-acetylimidazole on oxytocin binding in bovine mammary tissue

Journal Article · Mon Jan 01 04:00:00 UTC 1990 · Journal of Receptor Research; (USA)

DOI:https://doi.org/10.3109/10799899009064671· OSTI ID:5685065

Zhao, X; Gorewit, R C; Currie, W B ^[1]

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1. Cornell Univ., Ithaca NY (USA)

The effects of N-acetylimidazole on specific binding of oxytocin to microsomal fractions of bovine mammary gland were studied. N-acetylimidazole suppressed oxytocin binding, with time and concentration dependence. Decreased oxytocin binding activity appeared to be due to decreased affinity of the hormone for its receptor. Acetylation of oxytocin, rather than of oxytocin receptors, seemed to be responsible for the decreased binding.

• OSTI ID: 5685065
• Journal Information: Journal of Receptor Research; (USA), Journal Name: Journal of Receptor Research; (USA) Vol. 10:5-6; ISSN 0197-5110; ISSN JRERD
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETYLATION
ACYLATION
AFFINITY
ANIMALS
AZOLES
BIOCHEMICAL REACTION KINETICS
BODY
CATTLE
CELL CONSTITUENTS
CHEMICAL REACTIONS
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
GLANDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROGEN COMPOUNDS
IMIDAZOLES
IN VITRO
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MAMMARY GLANDS
MICROSOMES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
ORGANS
OXYTOCIN
PEPTIDE HORMONES
PITUITARY HORMONES
REACTION KINETICS
RIBOSOMES
RUMINANTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES