Familial site-specific Ovarian cancer is linked to BRCA1 on 17q12-21

Journal Article · Tue Nov 01 04:00:00 EST 1994 · American Journal of Human Genetics

OSTI ID:56832

Steichen-Gersdorf, E; Gallion, H H; Ponder, M A; Pye, C; Mazoyer, S; Smith, S A; Ponder, B A.J.; Ford, D; Easton, D F ^[1]; Girodet, C ^[2]

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1. Univ. of Cambridge, MA (United States)
2. Centre Jean Perrin, Clermont-Ferrand (France)

In a study of nine families with {open_quotes}site-specific{close_quotes} ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age <50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive. 17 refs., 3 figs., 1 tab.

• OSTI ID: 56832
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: 5 Vol. 55; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CHROMOSOMAL ABERRATIONS
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOME 17
HUMAN POPULATIONS
MAMMARY GLANDS
NEOPLASMS
OVARIES
RISK ASSESSMENT
STATISTICAL MODELS