Effects of environmental toxicants on development of a teleost embryo
Journal Article
·
· J. Environ. Pathol., Toxicol. Oncol.; (United States)
OSTI ID:5682992
Embryos of the teleost Fundulus heteroclitus are shown to be useful model systems for monitoring the effects of xenobiotic compounds on development. Fourteen different substances were tested: malathion, aroclor, aldrin, diquat, parathion, pentachlorophenol, sevin, toxaphene, lindane, 2,4-D, DDT, paraquat, 2,4,5-T, and aminotriazole. Concentrations used for each of these was from 0.01 to 10.0 ppm in the incubation dishes. The variety of effects on development observed depended on the compound and its concentration. These effects included inhibition of gastrulation, abnormal axis formation, diminished pigmentation, slowed rate of development, reduced frequency of hatching, loss of neuromuscular control, and reduction or inhibition of heart beat. Possible modes of action of some of these compounds are discussed. It is also shown that embryogenesis is not always the most susceptible part of the organism's life cycle.
- Research Organization:
- Trinity College, Hartford, CT
- OSTI ID:
- 5682992
- Journal Information:
- J. Environ. Pathol., Toxicol. Oncol.; (United States), Journal Name: J. Environ. Pathol., Toxicol. Oncol.; (United States) Vol. 2; ISSN JEPOE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDRIN
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
CARBOXYLIC ACID ESTERS
CHLORINATED AROMATIC HYDROCARBONS
DDT
ESTERS
FISHES
HALOGENATED AROMATIC HYDROCARBONS
HYDROXY COMPOUNDS
INSECTICIDES
MALATHION
ONTOGENESIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PARATHION
PESTICIDES
PHENOLS
POLLUTANTS
POLLUTION
THIOLS
THIOPHOSPHORIC ACID ESTERS
VERTEBRATES
WATER POLLUTION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDRIN
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
CARBOXYLIC ACID ESTERS
CHLORINATED AROMATIC HYDROCARBONS
DDT
ESTERS
FISHES
HALOGENATED AROMATIC HYDROCARBONS
HYDROXY COMPOUNDS
INSECTICIDES
MALATHION
ONTOGENESIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PARATHION
PESTICIDES
PHENOLS
POLLUTANTS
POLLUTION
THIOLS
THIOPHOSPHORIC ACID ESTERS
VERTEBRATES
WATER POLLUTION