Studies of the mortality of A-bomb survivors, report 7

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575949· OSTI ID:5682389

Wakabayashi, T; Kato, H; Ikeda, T; Schull, W J

The incidence of malignant tumors in the Radiation Effects Research Foundation (RERF) Life Span Study (LSS) sample in Nagasaki as revealed by the Nagasaki Tumor Registry was investigated for the period 1959-1978. (1) No bias in exposure status in data collection was revealed. Neither method of diagnosis nor reporting hospitals nor the frequency of ''doubtful'' cases differ by exposure dose. (2) The risk of radiogenic cancer definitely increases with radiation dose for leukemia, cancers of the breast, lung, stomach, and thyroid, and suggestively so for cancers of the colon and urinary tract and multiple myeloma. However, no increase is seen for cancer of the esophagus, liver gall bladder, uterus, ovary, or salivary gland or for malignant lymphoma. (3) In general, the relative risks based on incidence, that is, on the tumor registry data, are either the same or somewhat higher than those based on mortality in the same years; however, the absolute risk estimates (excess cancer per 10/sup 6/ Person Year Rad (PYR)) are far higher. (4) Since A-bomb radiation in Nagasaki consisted essentially of ..gamma.. rays, the present report provides a good opportunity to examine the shape of the dose-response curve for ..gamma.. exposures. Unfortunately, statistically one cannot actually distinguish one model from another among a simple linear, a quadratic, or a linear quadratic response. Further data are obviously necessary.

• Research Organization: Radiation Effects Research Foundation, Nagasaki, Japan
• DOE Contract Number: AC01-76EV03161
• OSTI ID: 5682389
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 93:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GAMMA RADIATION
GASTROINTESTINAL TRACT
GLANDS
HEMIC DISEASES
HUMAN POPULATIONS
INTESTINES
IONIZING RADIATIONS
JAPAN
LARGE INTESTINE
LEUKEMIA
LUNGS
MAMMARY GLANDS
MORTALITY
NAGASAKI
NEOPLASMS
ORGANS
PATHOGENESIS
POPULATIONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RESPIRATORY SYSTEM
RISK ASSESSMENT
STOMACH
THYROID
URINARY TRACT