Characterization of voltage calcium channels in a clonal pituitary cell line
Journal Article
·
· Life Sci.; (United States)
The authors have pharmacologically characterized voltage sensitive calcium channels (VSCCs) in GH/sub 3/ cells, an anterior pituitary clonal cell line known to secrete prolactin and growth hormone. Raising the medium K/sup +/ concentration from 5 to 50 mM caused an immediate increase in net /sup 45/Ca/sup 2 +/ uptake which remained apparent over a 15 minute time course. /sup 45/Ca/sup 2 +/ uptake was maximally stimulated nearly 10-fold over basal levels. This K/sup +/-induced stimulation of Ca/sup 2 +/ uptake was not prevented by 10-/sup 5/M tetrodotoxin or by replacing sodium with choline in the assay medium. Ca/sup 2 +/ uptake was, however, inhibited by several VSCC antagonists: nitrendipine, D-600, diltiazem and Ca/sup 2 +/. Further, the novel dihydropyridine VSCC agonists, BAY K8644 and CGP 28392, enhanced 50-mM K/sup +/-stimulated /sup 45/Ca/sup 2 +/ uptake and these effects were blocked by nitrendipine. 40 references, 3 figures.
- Research Organization:
- Univ. of Chicago Pritzker School of Medicine, IL
- OSTI ID:
- 5681978
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 36:23; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ALKALI METAL COMPOUNDS
ALKALI METALS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
AMINES
AMMONIUM COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
CADMIUM COMPOUNDS
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
CATIONS
CELL CULTURES
CHARGED PARTICLES
CHEMISTRY
CHOLINE
CLONE CELLS
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
GONADOTROPINS
HORMONES
HYDROXY COMPOUNDS
INHIBITION
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
LTH
METALS
NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
POTASSIUM COMPOUNDS
QUATERNARY COMPOUNDS
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
SECRETION
SODIUM
TRACER TECHNIQUES
UPTAKE
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ALKALI METAL COMPOUNDS
ALKALI METALS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
AMINES
AMMONIUM COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
CADMIUM COMPOUNDS
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
CATIONS
CELL CULTURES
CHARGED PARTICLES
CHEMISTRY
CHOLINE
CLONE CELLS
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
GONADOTROPINS
HORMONES
HYDROXY COMPOUNDS
INHIBITION
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
LTH
METALS
NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
POTASSIUM COMPOUNDS
QUATERNARY COMPOUNDS
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
SECRETION
SODIUM
TRACER TECHNIQUES
UPTAKE