Molecular epidemiology of childhood leukemia with emphasis on chemical exposures

Conference · Tue Dec 31 04:00:00 EST 1996

OSTI ID:567727

Buffler, P A; Smith, M T; Wood, S ^[1]; Reynolds, P ^[2]

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1. Univ. of California, Berkeley, CA (United States)
2. California Dept. of Health Services, Emeryville, CA (United States)

Developing markets in the Pacific Basin depend heavily on the production and export of consumer goods. The generation of hazardous waste as a by-product of industrial production can be linked to adverse health outcomes, such as childhood leukemia, in ways that are presently unknown. In California, exposures resulting from hazardous waste disposal are of concern in the etiology of childhood cancer. Approximately 63% of the 57 hazardous waste sites that the U.S. Environmental Protection Agency (USEPA) included in the national priority list under the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) statute were in the six-county San Francisco Bay area. This area includes California`s Silicon Valley, where a disproportionate majority of these sites are located. Although only one study links hazardous waste disposal to childhood leukemia evidence is accumulating that in utero and maternal pesticide exposures as well as chemical exposures during childhood are important in the etiology of childhood leukemia. This study investigates whether children with leukemia have common genetic changes, whether children with genetic changes experience common chemical exposures, and whether the occurrences of these genetic changes correspond to the same temporal sequence as exposure. The purpose of this paper is to describe the study design and report on the status of research activity. 10 refs., 1 fig., 3 tabs.

• Research Organization: Argonne National Lab., IL (United States)
• OSTI ID: 567727
• Report Number(s): CONF-9611157--; ON: DE97009015; CNN: Grant P42ESO47052
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
CHEMICAL WASTES
ETIOLOGY
GENE MUTATIONS
HAZARDOUS MATERIALS
INDUSTRIAL WASTES
LEUKEMIA
PESTICIDES
RESEARCH PROGRAMS