Pharmacokinetic disposition of 14C-glyburide in patients with varying renal function

Journal Article · Sat Mar 01 00:00:00 EST 1986 · Clin. Pharmacol. Ther.; (United States)

DOI:https://doi.org/10.1038/clpt.1986.46· OSTI ID:5677130

Pearson, J G; Antal, E J; Raehl, C L; Gorsch, H K; Craig, W A; Albert, K S; Welling, P G

The pharmacokinetics of 14C-labeled glyburide were studied in 13 men with varying degrees of renal impairment. Patients received a single, 5 mg oral dose of glyburide as a solution (10 microCi/ml/mg) after a high-carbohydrate breakfast. Serial plasma and breath samples were collected for 48 hours and urine and feces were collected for 5 to 7 days. Patients with normal to moderately impaired renal function (creatinine clearance (CLCR) of 29 to 131 ml/min/1.7 m2) had glyburide plasma t1/2 values of 2.0 to 5.0 hours, with no relationship between CLCR and glyburide clearance. One subject with severe renal impairment (CLCR = 5 ml/min/1.7 m2) had decreased glyburide clearance that resulted in a t1/2 of 11 hours. The elimination of metabolites was more dependent on renal status but was only significantly affected in the patient with severe renal impairment.

• Research Organization: Ferris State College, Big Rapids, MI
• OSTI ID: 5677130
• Journal Information: Clin. Pharmacol. Ther.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DRUGS
EXCRETION
ADSORPTION
BIOCHEMICAL REACTION KINETICS
CARBON 14 COMPOUNDS
CREATININE
FECES
METABOLISM
PATIENTS
RENAL CLEARANCE
TRACER TECHNIQUES
UROGENITAL SYSTEM DISEASES
AZOLES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CLEARANCE
DISEASES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
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ORGANIC COMPOUNDS
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REACTION KINETICS
SORPTION
WASTES
551001* - Physiological Systems- Tracer Techniques