Pharmacokinetic disposition of 14C-glyburide in patients with varying renal function

Journal Article · Fri Feb 28 23:00:00 EST 1986 · Clin. Pharmacol. Ther.; (United States)

DOI:https://doi.org/10.1038/clpt.1986.46· OSTI ID:5677130

Pearson, J G; Antal, E J; Raehl, C L; Gorsch, H K; Craig, W A; Albert, K S; Welling, P G

The pharmacokinetics of 14C-labeled glyburide were studied in 13 men with varying degrees of renal impairment. Patients received a single, 5 mg oral dose of glyburide as a solution (10 microCi/ml/mg) after a high-carbohydrate breakfast. Serial plasma and breath samples were collected for 48 hours and urine and feces were collected for 5 to 7 days. Patients with normal to moderately impaired renal function (creatinine clearance (CLCR) of 29 to 131 ml/min/1.7 m2) had glyburide plasma t1/2 values of 2.0 to 5.0 hours, with no relationship between CLCR and glyburide clearance. One subject with severe renal impairment (CLCR = 5 ml/min/1.7 m2) had decreased glyburide clearance that resulted in a t1/2 of 11 hours. The elimination of metabolites was more dependent on renal status but was only significantly affected in the patient with severe renal impairment.

• Research Organization: Ferris State College, Big Rapids, MI
• OSTI ID: 5677130
• Journal Information: Clin. Pharmacol. Ther.; (United States), Journal Name: Clin. Pharmacol. Ther.; (United States) Vol. 3; ISSN CLPTA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADSORPTION
AZOLES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CARBON 14 COMPOUNDS
CLEARANCE
CREATININE
DISEASES
DRUGS
EXCRETION
FECES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MATERIALS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
REACTION KINETICS
RENAL CLEARANCE
SORPTION
TRACER TECHNIQUES
UROGENITAL SYSTEM DISEASES
WASTES