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The normal and abnormal distribution of the adrenomedullary imaging agent m-(I-/sup 131/)iodobenzylguanidine (I-/sup 131/ MIBG) in man: evaluation by scintigraphy

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5672626
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The scintigraphic distribution of m-(/sup 131/I)iodobenzylguanidine (I-/sup 131/ MIBG), an adrenal medullary imaging agent, was studied to determine the patterns of uptake of this agent in man. The normal distribution of I-/sup 131/ MIBG includes clear portrayal of the salivary glands, liver, spleen, and urinary bladder. The heart, middle and lower lung zones, and colon were less frequently or less clearly seen. The upper lung zones and kidneys were seldom visualized. The thyroid appeared only in cases of inadequate thyroidal blockade. The ''normal'' adrenal glands were seldom seen and faintly imaged in 2% at 24 hr after injection and in 16% at 48 hr, in patients shown not to have pheochromocytomas, whereas intra-adrenal, extraadrenal, and malignant pheochromocytomas usually appeared as intense focal areas of I-/sup 131/ MIBG uptake at 24 through 72 hr.
Research Organization:
Div. of Nucl. Med., University of Michigan, Ann Arbor
OSTI ID:
5672626
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:8; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLADDER
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ENDOCRINE GLANDS
EVALUATION
GLANDS
IMAGES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MAN
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SALIVARY GLANDS
SCINTISCANNING
SPLEEN
URINARY TRACT
VERTEBRATES