Cerebrospinal fluid circulation: evaluation by single-photon and positron emission tomography

Journal Article · · AJNR, Am. J. Neuroradiol.; (United States)

OSTI ID:5672446

Bergstrand, G; Larsson, S; Bergstroem, M; Eriksson, L; Edner, G

Gamma camera cisternography after intrathecal administration of /sup 111/In-DTPA is a widely used and well established technique for studies of cerebrospinal fluid (CSF) circulation. The radiation dose from /sup 111/In, however, is a limiting factor that sometimes seriously affects the image quality and, hence, correct interpretation. This investigation was designed to assess the value of tomographic techniques for studies of CSF flow. Single-photon emission computed tomography (SPECT) was performed on 15 patients by means of the Karolinska Hospital rotating gamma camera system after injection of /sup 111/In-DTPA or /sup 99m/Tc-DTPA. The combination of SPECT and /sup 99m/Tc-DTPA proved to be a valuable technique. It permits a clear evaluation of the location of the isotope intracranially and its precise relation to the ventricles. Positron emission tomography (PET) applied after intrathecal administration of /sup 68/Ga-EDTA demonstrates that small amounts of radioactivity can be registered and that PET is a promising technique for the evaluation of CSF dynamics.

• Research Organization: Department of Neuroradiology, Karolinska Hospital, Stockholm, Sweden
• OSTI ID: 5672446
• Journal Information: AJNR, Am. J. Neuroradiol.; (United States), Journal Name: AJNR, Am. J. Neuroradiol.; (United States) Vol. 4:3; ISSN AAJND
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BRAIN
CAMERAS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
CHELATING AGENTS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
DTPA
EDTA
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GALLIUM 68
GALLIUM ISOTOPES
GAMMA CAMERAS
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES