Cesium in mammals: acute toxicity, organ changes and tissue accumulation

Journal Article · Thu Jan 01 04:00:00 EST 1981 · J. Environ. Sci. Health, Part A; (United States)

DOI:https://doi.org/10.1080/10934528109375003· OSTI ID:5672245

Pinsky, C ^[1]; Bose, R; Taylor, J R; McKee, J S.C.; Lapointe, C; Birchall, J

---

1. Univ. of Manitoba, Winnipeg, Canada

The acute toxicity of cesium given intraperitoneally (IP) as CsCl in mice is characterized by autonomic upset and by a multiphasic excitant-depressant action on the central nervous system. The predominantly depressant action can progress to respiratory embarrassment, cyanosis, spinal convulsions and death. Light microscopy of mice treated with 2.0 mEq Cs/sup +/ kg/sup -1/ IP for 14 days showed lymphoid hyperplasia in small intestine. Measurement of tissue cesium by the proton-induced x-ray emission (PIXE) technique is convenient and reproducible. Cesium displays a generalized bioactivity that merits further study.

• OSTI ID: 5672245
• Journal Information: J. Environ. Sci. Health, Part A; (United States), Journal Name: J. Environ. Sci. Health, Part A; (United States) Vol. A16:5; ISSN JESED
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ALKALI METAL COMPOUNDS
ALKALI METALS
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
CESIUM
CESIUM CHLORIDES
CESIUM COMPOUNDS
CHEMICAL ANALYSIS
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
GASTROINTESTINAL TRACT
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
INTESTINES
INTRAPERITONEAL INJECTION
LYMPHATIC SYSTEM
MAMMALS
METALS
MICE
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NONDESTRUCTIVE ANALYSIS
ORGANS
PIXE ANALYSIS
RESPIRATORY SYSTEM DISEASES
RODENTS
SMALL INTESTINE
TOXICITY
VERTEBRATES
X-RAY EMISSION ANALYSIS