Total lymphoid irradiation for treatment of intractable cardiac allograft rejection
- Stanford Univ.Medical Center, CA (USA)
The ability of postoperative total lymphoid irradiation to reverse otherwise intractable cardiac allograft rejection was examined in a group of 10 patients in whom conventional rejection therapy (including pulsed steroids and monoclonal or polyclonal anti-T-cell antibody therapy) had failed to provide sustained freedom from rejection. Follow-up periods range from 73 to 1119 days since the start of total lymphoid irradiation. No patient died or sustained serious morbidity because of the irradiation. Three patients have had no further rejection (follow-up periods, 105 to 365 days). Two patients died--one in cardiogenic shock during the course of total lymphoid irradiation, the other with recurrent rejection caused by noncompliance with his medical regimen. Total lymphoid irradiation appears to be a safe and a moderately effective immunosuppressive modality for 'salvage' therapy of cardiac allograft rejection unresponsive to conventional therapy.
- OSTI ID:
- 5669565
- Journal Information:
- Journal of Heart and Lung Transplant; (USA), Vol. 10:2; ISSN 1053-2498
- Country of Publication:
- United States
- Language:
- English
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BIOLOGICAL RADIATION EFFECTS
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PATIENTS
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CARDIOVASCULAR SYSTEM
ORGANS
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560151* - Radiation Effects on Animals- Man