Oxidation of biologically active reducing substances by ozone
Journal Article
·
· Arch. Environ. Health; (United States)
Cysteine, reduced glutathione, thioglycolic acid, NADH and NADPH are readily oxidized by ozone. When glutathione is oxidized, the product is not reducible by the biological system of glutathione reductase and NADPH. NADH and NADPH are biologically active as coenzymes, however, after oxidation. Sulfhydryl enzymes, papain, and glyceraldehyde 3-phosphate dehydrogenase are also inactivated by ozone even in the presence of cysteine. The inactive form of the enzymes is only partially reactivated by cysteine. Other sulfhydryl reagents provide only partial protection of papain against ozone. Selenocysteine in combination with cysteine is a highly effective protector. These data suggest that ozone may act by oxidation of sulfhydryl compounds, and especially sulfhydryl enzymes, to higher oxidation states than the disulfide which is not reducible by the reductases available in cells. Seleno compounds may be important cellular protectors. 14 references, 5 tables.
- Research Organization:
- Battelle Pacific Northwest Lab., Richland, WA
- OSTI ID:
- 5666235
- Journal Information:
- Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 23; ISSN AEHLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
BIOCHEMICAL REACTION KINETICS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
COENZYMES
CYSTEINE
DATA
DRUGS
ENZYMES
EXPERIMENTAL DATA
GLUTATHIONE
GLYCOLIC ACID
HYDROLASES
HYDROXY ACIDS
INACTIVATION
INFORMATION
KINETICS
MONOCARBOXYLIC ACIDS
NAD
NADP
NUCLEOTIDES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDATION
OXIDOREDUCTASES
OZONE
PAPAIN
PEPTIDE HYDROLASES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
REAGENTS
REDOX REACTIONS
RESPONSE MODIFYING FACTORS
SH-PROTEINASES
THIOLS
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
BIOCHEMICAL REACTION KINETICS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
COENZYMES
CYSTEINE
DATA
DRUGS
ENZYMES
EXPERIMENTAL DATA
GLUTATHIONE
GLYCOLIC ACID
HYDROLASES
HYDROXY ACIDS
INACTIVATION
INFORMATION
KINETICS
MONOCARBOXYLIC ACIDS
NAD
NADP
NUCLEOTIDES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDATION
OXIDOREDUCTASES
OZONE
PAPAIN
PEPTIDE HYDROLASES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
REAGENTS
REDOX REACTIONS
RESPONSE MODIFYING FACTORS
SH-PROTEINASES
THIOLS