Effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages

Journal Article · Mon Apr 01 00:00:00 EST 1985 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(85)90030-1· OSTI ID:5661845

Karp, W B; Gale, T F; Subramanyam, S B; DuRant, R H

This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorlyase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.

• Research Organization: Medical College of Georgia, Augusta
• OSTI ID: 5661845
• Journal Information: Environ. Res.; (United States), Vol. 36:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CYTOCHROME OXIDASE
ENZYME ACTIVITY
MERCURY
TOXICITY
OXIDOREDUCTASES
ACETATES
EXPERIMENTAL DATA
FETAL MEMBRANES
FETUSES
HAMSTERS
KIDNEYS
PREGNANCY
SINGLE INTAKE
TIME DEPENDENCE
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
DATA
ELEMENTS
ENZYMES
HAEM DEHYDROGENASES
INFORMATION
INTAKE
MAMMALS
MATERIALS
MEMBRANES
METALS
NUMERICAL DATA
ORGANS
RODENTS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)