Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate

Journal Article · Fri Mar 15 04:00:00 EST 1985 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(85)90182-6· OSTI ID:5661806

Weyel, D A; Schaffer, R B

The use of isocyanates in industry has been increasing and, therefore, the potential for human exposure has also increased. Two such isocyanates are diphenylmethane-4,4'-diisocyanate (MDI) and dicyclohexylmethane-4,4'-diisocyanate (SMDI). The pulmonary irritation of the aromatic isocyanate MDI and the sensory and pulmonary irritation of the cycloaliphatic isocyanate SMDI were studied in an animal bioassay. Groups of male, Swiss-Webster mice were exposed to aerosol concentrations of MDI varying from 17 to 67 mg/m3. The total exposure time for both isocyanates was 240 min, and the respiratory patterns and frequency of four mice were recorded during each exposure. Concentrations of MDI and SMDI in the exposure chamber were determined gravimetrically. The mass median aerodynamic diameter (MMAD) and geometric standard deviation for the MDI aerosol were 0.7 micron and 1.6 and for the SMDI aerosol were 0.9 micron and 1.5, respectively. The inhalation responses during the 4-hr exposures to aerosols of MDI and SMDI were investigated, and the animal model was used to determine time-response and concentration-response relationships for all exposures. From these results it was determined that the level of effect was dependent on both the duration of exposure and the exposure concentration.

• Research Organization: Univ. of Pittsburgh, PA
• OSTI ID: 5661806
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 77:3; ISSN TXAPA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMALS
BIOASSAY
BIOLOGICAL MODELS
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RODENTS
SAFETY STANDARDS
SENSE ORGANS
SENSE ORGANS DISEASES
SIZE
SOLS
STANDARDS
TOXICITY
VERTEBRATES