Evaluation of OECD guidelines for testing of chemicals with aquatic organisms
The protocols in the OECD (Organization for Economic Cooperation and Development) guidelines for testing of chemicals with aquatic organisms were evaluated for the following tests: (1) Fish, Acute Toxicity Test, (2) Bioaccumulation: Flow-through Fish Test, (3) Daphnia sp., 14-day Reproduction Test (including an Acute Immobilization Test), and (4) Alga, Growth Inhibition Test. The protocols were evaluated by conducting the tests with different classes of chemicals (i.e., water soluble, less water soluble requiring a chemical carrier, and volatile chemical). Flow-through and semistatic Fish, Acute Toxicity Tests were conducted with cupric chloride and acridine. The Bioaccumulation Flow-Through Fish Test was conducted with naphthalene and DDE. Three chemicals - cupric chloride, acridine, and di-n-butyl phthalate - were used to evaluate the Daphnia sp., 14-day Reproduction Test. The Alga, Growth Inhibition Test was evaluated with three chemicals: cupric chloride, acridine, and paradichlorobenzene. By following the OECD guidelines in conducting these tests, results were obtained that are comparable with literature data obtained with other methods. An evaluation of each test protocol is given with recommendations for the guidelines for conducting the tests.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5652737
- Report Number(s):
- ORNL-5942; ON: DE84002258
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Aquatic-- Regulations -- (-1989)
54 ENVIRONMENTAL SCIENCES
ACRIDINES
ALGAE
ANIMALS
AQUATIC ORGANISMS
AROMATICS
ARTHROPODS
AZINES
BENZOPYRENE
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BRANCHIOPODS
CARBOXYLIC ACIDS
CHLORELLA
CHLORIDES
CHLORINATED AROMATIC HYDROCARBONS
CHLORINE COMPOUNDS
CONDENSED AROMATICS
COPPER CHLORIDES
COPPER COMPOUNDS
COPPER HALIDES
CRUSTACEANS
DAPHNIA
DICARBOXYLIC ACIDS
EVALUATION
FISHES
HALIDES
HALOGEN COMPOUNDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INTERNATIONAL ORGANIZATIONS
INVERTEBRATES
LAWS
MICROORGANISMS
NAPHTHALENE
NATIONAL ORGANIZATIONS
OECD
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHTHALIC ACID
PLANTS
PYRIDINES
RECOMMENDATIONS
REPRODUCTION
TOXIC SUBSTANCES CONTROL ACT
TOXICITY
TRANSITION ELEMENT COMPOUNDS
UNICELLULAR ALGAE
US EPA
US ORGANIZATIONS
VERTEBRATES