Neuropsychiatric manifestations of alkali metal deficiency and excess

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Pharmacol., Biochem. Behav.; (United States)

DOI:https://doi.org/10.1016/0091-3057(84)90166-7· OSTI ID:5650439

Yung, C Y

The alkali metals from the Group IA of the periodic table (lithium, sodium, potassium, rubidium, cesium and francium) are reviewed. The neuropsychiatric aspects of alkali metal deficiencies and excesses (intoxications) are described. Emphasis was placed on lithium due to its clinical uses. The signs and symptoms of these conditions are characterized by features of an organic brain syndrome with delirium and encephalopathy prevailing. There are no clinically distinctive features that could be reliably used for diagnoses. Sodium and potassium are two essential alkali metals in man. Lithium is used as therapeutic agent in bipolar affective disorders. Rubidium has been investigated for its antidepressant effect in a group of psychiatric disorders. Cesium is under laboratory investigation for its role in carcinogenesis and in depressive illness. Very little is known of francium due to its great instability for experimental study.

• Research Organization: Texas Tech Univ. Health Sciences Center, School of Medicine, Lubbock
• OSTI ID: 5650439
• Journal Information: Pharmacol., Biochem. Behav.; (United States), Vol. 21 Suppl 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRAIN
INJURIES
CESIUM
NUTRITIONAL DEFICIENCY
TOXICITY
FRANCIUM
LITHIUM
POTASSIUM
RUBIDIUM
SODIUM
MENTAL DISORDERS
ALKALI METALS
BODY
CENTRAL NERVOUS SYSTEM
ELEMENTS
METALS
NERVOUS SYSTEM
ORGANS
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)